Systemic Phosphate Elevations Induce Fibroblast Growth Factor 23 Production in Skeletal Muscle to Reduce Renal Phosphate Reabsorption in Mice
Phosphate elevations induced FGF23 expression in skeletal muscle, independent of the absence or presence of CKD. Skeletal muscle-derived FGF23 reduced renal phosphate reabsorption.
Authors
- Kylie Heitman (ORCID: https://orcid.org/0000-0002-5345-2727)
- Glenn C. Rowe (ORCID: https://orcid.org/0000-0002-8195-9605)
- Abul Fajol (ORCID: https://orcid.org/0000-0002-3202-5697)
- Jorge Gamboa (ORCID: https://orcid.org/0000-0002-4204-7670)
- Christopher Yanucil
- Orlando M. Gutiérrez (ORCID: https://orcid.org/0000-0001-6593-3571)
- David G. Westbrook
- Matthew Denniff
- Matthew S. Alexander (ORCID: https://orcid.org/0000-0001-7406-5171)
- Christian Faul (ORCID: https://orcid.org/0000-0002-7512-0977)
- Abolfazl Zarjou
- Emma L. Watson
- Kenneth E. White
- Dungeng Peng
- Qing Li
- S. Madison Thomas
- Brian Czaya
- Syed Wasiuddin
Institutions
- University of Leicester (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Civitan International (US)
- Children's of Alabama (US)
- University of Alabama at Birmingham (US)
- NIHR Leicester Biomedical Research Centre (GB)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1681/asn.0000000963
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00