A Comparative Study of the Tabletability of Amorphous and Crystalline Forms of Organic Drugs

Understanding differences in compression behavior between amorphous and crystalline forms of organic drugs provides valuable insights into how amorphization affects tabletability, which is critical for the rational development of pharmaceutical tablets. In this work, we evaluate the compaction properties of both solid forms across several structurally diverse model drugs and found that the tabletability profiles of amorphous forms cluster within a narrower range than those of their crystalline counterparts. Moreover, the differences observed at high compaction pressures are primarily governed by variations in interparticulate bonding strength, as supported by infrared spectroscopy. Finally, we discuss the broader implications of these findings for the design and development of amorphous solid dispersions in tablet formulations.