Effects of Dietary Supplementation with Coriander Seed Powder on Serum Lipid Profile, Glycemic Indices, and Oxidative Stress Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial

This study aimed to investigate the effects of coriander seed supplementation on serum lipid profiles, glycemic indices, and oxidative stress biomarkers in patients with type 2 diabetes mellitus (T2DM). In total, 40 such patients aged 30－60 years were allocated into two groups receiving either coriander seed powder (1,000 mg/d, n=20) or placebo (1,000 mg/d, n=20) for 6 weeks. Serum lipid profile: total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs); anthropometric measurements; dietary intake; and biochemical parameters including fasting blood serum (FBS), serum insulin, homeostatic model assessment for insulin resistance (HOMA-IR), and malondialdehyde (MDA); and total antioxidant capacity (TAC) were assessed before and after supplementation. Coriander seed powder markedly reduced the FBS (156.15±23.19 to 130.30±21.15 mg/dL), serum insulin (17.72±0.47 to 17.12±0.76 µU/mL), HOMA-IR (6.82±0.95 to 5.52±0.99), TC (183.85±55.68 to 145.20±31.36 mg/dL), TG (152.50±37.59 to 130.40±27.96 mg/dL), LDL-C (127.35±23.45 to 111.40±25.71 mg/dL), and MDA (1.65±0.15 to 1.49±0.15 nmol/mL). However, the serum TAC significantly increased (1.93±0.12 to 1.97±0.09 mmol/L) (<i>P</i><0.05). Anthropometric measurements did not differ remarkably between groups. Post-dose significant inter-group differences in FBS, serum insulin, HOMA-IR, TC, TG, LDL-C, MDA, and TAC levels were identified after adjusting for baseline values (<i>P</i><0.05). This study demonstrated that coriander seed supplementation positively improved glycemic indices, lipid profile, and oxidative stress status in patients with T2DM, suggesting its potential as a useful complementary treatment for managing this condition.