<i>THEMIS2</i> as a Novel Mediator of <i>VEGFR2</i> -driven Angiogenesis in Breast Cancer: Functional Suppression by miR-125b-5p
We unraveled a novel <i>miR-125b-5p-THEMIS2-VEGFR2</i> signaling axis as a key modulator of breast cancer metastasis and chemoresistance. These findings provide mechanistic insight and suggest that <i>miR-125b-5</i>p or <i>THEMIS2</i> may serve as therapeutic targets or prognostic biomarkers in aggressive breast cancers.
Authors
- Che-Ju Chang (ORCID: https://orcid.org/0000-0002-5400-6905)
- Shiao-Lin Tung (ORCID: https://orcid.org/0000-0002-6241-6293)
- Ing-Shiow Lay
- Chih-chiu Chiang
- WAN-TING LIAO
- YU-WEN TSENG
- WEI-CHIEH HUANG
- HEN-HONG CHANG
Institutions
- National Chung Hsing University (TW)
- China Medical University (TW)
- China Medical University Beigang Hospital (TW)
- Chang Bing Show Chwan Memorial Hospital (TW)
- China Medical University Hospital (TW)
- County Hospital (GB)
- American Association of Nurse Practitioners (US)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-12-30
- DOI
- https://doi.org/10.21873/anticanres.17926
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology, Taiwan
- China Medical University
- China Medical University, Taiwan