STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy–lysosome machinery

STUB1 directly binds to PGC-1α and promotes its ubiquitination and degradation, thereby inhibiting the TFEB-dependent autophagy-lysosome pathway and inducing hippocampal neuronal apoptosis, ultimately contributing to POCD in aged mice. This study provides a novel theoretical basis for understanding the pathogenesis of POCD and identifies potential therapeutic targets.