Precision synthesis of peptide chimeras through site-specific azomethine ylide–dehydroalanine cycloaddition
An Ag-catalyzed N-terminus/dehydroalanine [3 + 2] cycloaddition enables site-specific peptide–peptide conjugation. Chiral ( S )- and ( R )-DTBM-SEGPHOS ligands control pyrrolidine stereochemistry independently of the peptide backbone.
Authors
- Eunsang Kwon
- Sena Miura
- Yuzuki Takami
- Hibiki Ohno
- Masaki Iwata
- Naohiko Yoshikai
- Kazuya Kanemoto
Institutions
- Tohoku University (JP)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1039/d5qo01627d
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00