Functional Connectivity to the Cerebellum and Resting‐State Networks Predict Earlier Improvement of Dystonia Following Globus Pallidus Internus‐Deep Brain Stimulation ( <scp>GPi‐DBS)</scp>
These findings support a broader network model integrating cerebellum, limbic system, and basal ganglia in dystonia. Stimulation of cerebellar-connected circuits may accelerate improvement independent of classical somatomotor networks. Results highlight novel targets and mechanisms for improving DBS effectiveness, suggesting multitarget, network-informed strategies could enhance therapeutic outcomes. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Coralie de Hemptinne (ORCID: https://orcid.org/0000-0003-2780-3666)
- Chance Fleeting
- Aashay Patel (ORCID: https://orcid.org/0000-0003-3301-8066)
- Marta San Luciano (ORCID: https://orcid.org/0000-0002-9885-704X)
- Vyshak Chandra
- Kelly D. Foote (ORCID: https://orcid.org/0000-0002-2436-4138)
- Joshua K. Wong (ORCID: https://orcid.org/0000-0002-4632-3417)
- Justin D. Hilliard
- Michael S. Okun
- A. Enrique Martinez‐Nunez
Institutions
- University of California, San Francisco (US)
- University of Florida (US)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1002/mds.70152
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00