Agitation and anxiety features define a more severe phenotype in unipolar depression

Features of agitated depression define a more severe depressive phenotype within depressive episodes and may represent a clinically relevant dimension in unipolar MDD. A transdiagnostic approach may enhance future research and treatment strategies.

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Publication Details

Journal
Psychiatry Research
Published
2025-12-30
DOI
https://doi.org/10.1016/j.psychres.2025.116928
Primary Topic
Neurotransmitter Receptor Influence on Behavior
Type
article
Field-Weighted Citation Impact
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article

Agitation and anxiety features define a more severe phenotype in unipolar depression

Erika Vitali, Gabriele Nibbio, Raffaele Ferri, Panagiotis P. Ferentinos et al.
Psychiatry Research
Neurotransmitter Receptor Influence on Behavior
article

Agitation and anxiety features define a more severe phenotype in unipolar depression

Erika Vitali, Gabriele Nibbio, Raffaele Ferri, Panagiotis P. Ferentinos, Vincenzo Dattilo, Giulia Perusi, Maria Luca, Massimo Gennarelli, Lisa Buson, Stefano Paolini, Stefano Bignotti, Beatrice Lana, Daniel Souery, Alessia Muscarella, Valentina Menesello, Rosana Carvalho Silva, Chiara Cobelli, Alessandra Minelli, Mattia Meattini, Chiara Galbiati, Raffaella Zanardi, Irene Calzavara Pinton, Antonio Baglioni, Chiara Magri, Anna Magistrali, Ughetta Bosco Umbertino, Edoardo Giacopuzzi, Joseph Zohar, Antonio Vita, Nicola Necchini, Stuart Montgomery, Julien Mendlewicz, Edoardo Spina, Stefano Barlati, Alessandro Serretti, Giovanni Battista Tura, Monica Scaglia, Lorenzo Bertoni, Dan Rujescu, Paolo Martini, Antonina Luca, Siegfried Kasper
article en

Abstract

Features of agitated depression define a more severe depressive phenotype within depressive episodes and may represent a clinically relevant dimension in unipolar MDD. A transdiagnostic approach may enhance future research and treatment strategies.

Psychiatry ResearchVol. 357
Université Libre de Bruxelles (BE), Oasi Maria SS (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), University of Brescia (IT)
Good health and well-being
Openalex Percentile: Top 36%
Neurotransmitter Receptor Influence on Behavior
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