Transperineal Versus Transrectal Prostate Biopsy: A Systematic Review and Meta-analysis of Randomized Controlled Trials Across Settings With and Without Magnetic Resonance Imaging Targeting

We compared evidence for two prostate biopsy methods: transperineal (TP) and transrectal (TR). Both were similar in detecting prostate cancer, but the TP method had fewer infections and may not require antibiotics. TP may cause slightly more discomfort, but pain is generally manageable with local anesthesia. Which approach is best may depend on factors such as the availability of MRI (magnetic resonance imaging), the risk of infection, and the patient's preference.