Electroacupuncture ameliorates glycolipid metabolism disorder in skeletal muscle of type 2 diabetic rats via modulation of the AMPK/PGC-1α/TFAM signaling pathway
EA improves glycolipid metabolism and alleviates insulin resistance in T2DM rats, potentially via activation of the AMPK/PGC-1α/TFAM pathway. These effects may be linked to improved skeletal muscle function and glucose utilization. EA shows promise as a therapeutic strategy for T2DM, warranting further investigation into its mechanisms and clinical relevance.
Authors
- Hanhan Chen
- jiangnan Ye
- Zhuoxuan Li (ORCID: https://orcid.org/0000-0002-9380-888X)
- Chengguo Su (ORCID: https://orcid.org/0000-0001-8578-3494)
- Furong Zhang
- Chang Liu
- Wei Zhang
- Qunwen Lu
- Fang Luo
- Junjie Feng
- Jumahan Nverjiang
- Jun Zhu
Institutions
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1186/s13098-025-01960-w
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Sichuan Province