Simulation-Based Assessment of Empirical Amikacin Dosing in High-Risk Adults With Febrile Neutropenia and Hematological Malignancies Using Population Pharmacokinetic Modeling
Renal function and serum albumin substantially affect amikacin exposure. Therefore, model-informed dosing strategies may be required to optimize empirical amikacin therapy in high-risk patients with neutropenia and hematological malignancies.
Authors
- Sabariah Noor Harun (ORCID: https://orcid.org/0000-0001-8476-7425)
- Siti Maisharah Sheikh Ghadzi
- Guan Chin Leong
- Jared Tun Fang Loo
Institutions
- RCSI & UCD Malaysia Campus (MY)
- Universiti Sains Malaysia (MY)
- Hospital Pulau Pinang (MY)
- Penang Adventist Hospital (MY)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1097/ftd.0000000000001421
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00