Automating tumor–stroma ratio quantification in colon cancer patients from the UNITED study
We validated a clinically applicable tool for fully automated TSR quantification in colon cancer, including an optimal region of interest and cut-off value for automated scoring. We confirm the independent prognostic value of automated TSR for DFS and OS and highlight its influence on potential ACT benefit, underlining its clinical relevance. Our findings support its integration into digital pathology workflows.
Authors
- Darko Dzambaz
- Meaghan Polack (ORCID: https://orcid.org/0000-0001-7980-7533)
- Koen Peeters (ORCID: https://orcid.org/0000-0002-9332-1334)
- Natalja E Leeuwis-Fedorovich
- Gabi W. van Pelt (ORCID: https://orcid.org/0000-0003-1449-7348)
- Joop van Baarlen
- Pance Karagjozov
- Mark P.S. Sie
- Gordana Petrushevska
- Valeska Terpstra
- Mário Fontes-Sousa (ORCID: https://orcid.org/0000-0003-0337-3251)
- Emma Witteveen
- Adriana Zucchiatti (ORCID: https://orcid.org/0000-0001-8898-0848)
- Svetozar Antović (ORCID: https://orcid.org/0000-0003-3068-4987)
- Frédérique H. Beverdam
- Rob AEM. Tollenaar
- René Arensman
- K.C.M.J. Peeters
- Gorana Gašljević (ORCID: https://orcid.org/0000-0002-8332-3627)
- M. T. Rodrigo
- Wilma E. Mesker (ORCID: https://orcid.org/0000-0001-5533-4778)
- Koen Talsma
- Marloes Smit (ORCID: https://orcid.org/0000-0002-3961-5040)
- Maria João Brito (ORCID: https://orcid.org/0000-0001-9019-0116)
- Iván Archilla Sanz
- Vink G.R.
- Nicole W.J. Bulkmans
- Shonali Natu (ORCID: https://orcid.org/0009-0002-1147-2727)
- Ronald Hoekstra
- A. Stijn L. P. Crobach
- Miriam Koopman
- Floor Heilijgers
- Slavica Kostadinova Kunovska
- Magdalena Bogdanovska Todorovska
- E.M.V. de Cuba
- A.G.H. Roodvoets
- S. Landolfi
- R. Buettner
- Roger Feakins
- Arash Bordbar
- A. Raimundo
- M.P. Hendriks
- M. Vermaas
- Maud Strous
- R. Souza da Silva
- Els Dequeker
- M.M. Lacle
- Y. Tolkach
- Raed Al Dieri
- L. Mekenkamp
- J. Han van Krieken
- Arjan van Tilburg
- W.E. Mesker
- F. Heilijgers
- H. Gelderblom
- J.W.T. Dekker
- Elma Meershoek-Klein Kranenbarg
- Hein Putter
- M. Cuatrecasas
- Paula Borralho Nunes
- S. Simonetti
- S. Kjaer-Frifeldt
- Jan Jansen
- João Manuel B. F. Cruz
- Pance Zdravkovski
- E. Meershoek - Klein Kranenbarg
- M. Polack
- Jan Lindebjerg
Institutions
- Leiden University Medical Center (NL)
- University Hospital Cologne (DE)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105934
- Citations
- 1
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Amgen
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Sanofi
- Les Laboratories Pierre Fabre
- European Society for Medical Oncology
- Servier
- Dutch Colorectal Cancer Group
- Sirtex Medical