Overcoming impaired antigen presentation in tumor-draining lymph nodes facilitates immunotherapy
This study demonstrates that tumor-induced impairments in antigen presentation in tumor-draining lymph nodes can be overcome by the appropriate introduction of immunological adjuvant to tumor-distant lymph nodes or by restoring IL-1β to the tumor-draining lymph node. These strategies can induce high-quality, durable immune responses and have clinical implications for expanding the efficacy of immunotherapies.
Authors
- Lance L. Munn (ORCID: https://orcid.org/0000-0003-0698-7232)
- Jessalyn M. Ubellacker (ORCID: https://orcid.org/0000-0002-7855-9125)
- Genevieve Marie Boland (ORCID: https://orcid.org/0000-0002-7522-6173)
- Lutz Menzel (ORCID: https://orcid.org/0000-0002-3816-6255)
- Johanna J. Rajotte (ORCID: https://orcid.org/0009-0001-8764-2350)
- Sonia Cohen (ORCID: https://orcid.org/0000-0003-0172-5620)
- Hengbo Zhou (ORCID: https://orcid.org/0000-0002-9948-7909)
- Mohammad R. Nikmaneshi (ORCID: https://orcid.org/0000-0002-9016-1830)
- Timothy P. Padera (ORCID: https://orcid.org/0000-0002-3453-9384)
- James W. Baish (ORCID: https://orcid.org/0000-0003-4442-4668)
- Meghan J. O’Melia (ORCID: https://orcid.org/0000-0003-2223-1849)
- Neian Contreras-Alvarado
- Lingshan Liu
- Xingjian Zhang
- Pin-Ji Lei
Institutions
- Bucknell University (US)
- Harvard University (US)
- University of Puerto Rico System (PR)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/jitc-2025-013364
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Breast Cancer Alliance
- Melanoma Research Alliance
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- National Institutes of Health