Sialic Acid-Fibronectin–negative and CD-44–positive Pancreatic Cancer Has a Poor Prognosis Due To Epithelial-Mesenchymal Transition
In blood S-FN-negative cases with depleted autocrine FN, therapeutic effects were reduced owing to the increased presence of VPCs, presumed to be CAFs induced by EMT. CD-44-positive PDAC cells, which are partially EMT cells, are prone to early distant metastasis.
Authors
- Hiroshi Takeyama
- Michinori Matsumoto (ORCID: https://orcid.org/0000-0002-5860-1103)
- Takeshi Gocho (ORCID: https://orcid.org/0000-0002-8463-905X)
- Yoshinobu Manome (ORCID: https://orcid.org/0000-0002-8755-8976)
- TAKAAKI YAMASHITA
- TOMOYUKI TANAKA
- TORU IKEGAMI
- TARO SAKAMOTO
Institutions
- Jikei University School of Medicine (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-12-30
- DOI
- https://doi.org/10.21873/anticanres.17965
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00