Artesunate preserves post-resuscitation myocardial and neurologic function in a rat model of cardiac arrest and cardiopulmonary resuscitation

This study demonstrated that Art reduces the severity of post-resuscitation myocardial and neurologic dysfunction, improves survival duration in a rat model of CA. The underlying mechanism may be related to anti-inflammation, oxidative stress and may be associated with regulation of 4-HNE induced p38 Mitogen activated protein kinase (MAPK) pathway activation.

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Publication Details

Journal
Resuscitation Plus
Published
2025-12-30
DOI
https://doi.org/10.1016/j.resplu.2025.101214
Primary Topic
Cardiac Arrest and Resuscitation
Type
article
Field-Weighted Citation Impact
0.00
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article

Artesunate preserves post-resuscitation myocardial and neurologic function in a rat model of cardiac arrest and cardiopulmonary resuscitation

Mary Ann Peberdy, W Tang, Joseph P. Ornato, Hui Li et al.
Resuscitation Plus
Cardiac Arrest and Resuscitation
article

Artesunate preserves post-resuscitation myocardial and neurologic function in a rat model of cardiac arrest and cardiopulmonary resuscitation

Mary Ann Peberdy, W Tang, Joseph P. Ornato, Hui Li, Guozhen Zhang, Min Yang, Cheng Cheng, Tao Jin, Lian Liang
article en

Abstract

This study demonstrated that Art reduces the severity of post-resuscitation myocardial and neurologic dysfunction, improves survival duration in a rat model of CA. The underlying mechanism may be related to anti-inflammation, oxidative stress and may be associated with regulation of 4-HNE induced p38 Mitogen activated protein kinase (MAPK) pathway activation.

Resuscitation PlusVol. 27
Virginia Commonwealth University (US), Anhui Medical University (CN), University Health System (US), First Affiliated Hospital of Anhui Medical University (CN), Second Affiliated Hospital of Anhui Medical University (CN), Children's Hospital of Richmond at VCU (US)
Good health and well-being
Openalex Percentile: Top 25%
Cardiac Arrest and Resuscitation
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