Prognostic value of LPAR1 expression and methylation in low-grade gliomas: a meta-analysis of TCGA and CGGA datasets and functional validation
Low LPAR1 expression or high LPAR1 methylation level was a potential prognostic molecular marker for favorable survival in LGG. Moreover, we identified a regulatory pattern in which a high level of LPAR1 methylation resulted in a decrease in LPAR1 expression, which affected the proportion of TIICs in TME. This pattern may work through CSK and Th1/Th2 pathways. Inhibiting LPAR1 can suppress the biological behavior of glioma cells in vitro. These findings open up new avenues for therapeutic and prognostic evaluation of LGG.
Authors
- Chenbin Bian
- L. Liang
- Song Luo (ORCID: https://orcid.org/0000-0002-4516-1444)
- Hongbin Wang
- Xin You
- Zhang Li (ORCID: https://orcid.org/0000-0003-4823-7480)
- Hongmin Chen
- Wenyi Liang
- Wang Feng
Institutions
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- Sichuan Cancer Hospital (CN)
- Sichuan Provincial Hospital of Traditional Chinese Medicine (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1186/s12885-025-15406-z
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00