Atraric Acid Mitigates Mitochondrial Dysfunction and Inflammation via AMPKα–PGC-1α Signaling in Metabolic-Associated Fatty Liver Disease
AA mitigates MASLD by activating the AMPK-PGC-1α axis, restoring mitochondrial function, and reducing ROS-driven inflammation. These findings highlight AA as a promising candidate for MASLD therapy and warrant further clinical investigation. <i>Antioxid. Redox Signal.</i> 44, 332-356.
Authors
- Tianyue Guan
- Xinran Li (ORCID: https://orcid.org/0000-0003-4182-3989)
- Yannan Xiang
- Zihan Xu
- Hongyu Huang
- Zhihao Ma
- Panpan Zhao
- Lei Wang
Institutions
- Xuzhou Medical College (CN)
- Lianyungang Oriental Hospital (CN)
- Kanion Pharmaceutical (China) (CN)
- The First People’s Hospital of Lianyungang (CN)
Publication Details
- Journal
- Antioxidants and Redox Signaling
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1177/15230864251406293
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00