SNHG11 as a Novel Biomarker Promoting Tumor Progression and Oxidative Phosphorylation in Clear Cell Renal Cell Carcinoma

<p indent="0mm">Kidney renal clear cell carcinoma (KIRC) is the most common and aggressive subtype of renal cell carcinoma and is characterized by poor prognosis and high molecular heterogeneity. Long noncoding RNAs (lncRNAs) have emerged as crucial regulators in cancer, yet the functional role of SNHG11 in KIRC remains unclear. In this study, we performed integrated multiomics analysis using data from the TCGA and ICGC cohorts and revealed that SNHG11, a methylation-associated lncRNA, was significantly correlated with poor clinical outcomes. <italic>In vitro</italic> and <italic>in vivo</italic> assays demonstrated that SNHG11 promotes tumor proliferation and progression. Mechanistically, SNHG11 enhances oxidative phosphorylation, as evidenced by increased ATP production, disrupted mitochondrial membrane potential, and altered NAD⁺/NADH ratios. Furthermore, SNHG11 expression was associated with somatic mutation patterns, particularly those involving BAP1 and PBRM1, indicating potential crosstalk between epigenetic regulation and genetic alterations. These findings reveal that SNHG11 is a novel biomarker in KIRC and a potential therapeutic target.