NAT10-Mediated ac4C-Modification Exacerbates Ferroptosis by Stabilizing HMOX1 in Deep Vein Thrombosis
Collectively, our data elucidate that downregulation of NAT10 mitigates endothelial ferroptosis and prevents DVT formation and progression by modulating HMOX1 expression, which offers a potential novel strategy for the prevention and treatment of thrombosis in DVT.
Authors
- Tingting Zhang (ORCID: https://orcid.org/0000-0002-2612-0014)
- W. Li
- Ran Wei (ORCID: https://orcid.org/0000-0002-9537-8481)
- Nannan Fan
- Xia Liu (ORCID: https://orcid.org/0000-0002-9209-0562)
- Y. Zhang
- Bin Wang (ORCID: https://orcid.org/0000-0001-6357-048X)
- Fei Xu (ORCID: https://orcid.org/0009-0000-2452-937X)
- Haowei Zu (ORCID: https://orcid.org/0009-0008-7612-9587)
- Xiaoyan Yu (ORCID: https://orcid.org/0000-0002-0748-3522)
- Xia Li
- Zhen Zhang
- Feifei Shi
- Fang Li
- Qiaoqiao Han
- Chu Chu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1161/atvbaha.125.323986
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00