Molecular Docking and Inhibition of Phosphatidylinositol 3-kinase by Quercetin and Isoquercetin from <i>Streptomyces griseoaurantiacus</i> HNF214

The microbial-derived quercetins effectively induce apoptosis and inhibit HepG2 proliferation by inactivating the PI3K/Akt/mTOR signaling pathway. Quercetin is specifically predicted to directly inhibit PI3K and AKT proteins, underscoring the potential of these compounds as targeted anticancer candidates.

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Publication Details

Journal
Anticancer Research
Published
2025-12-30
DOI
https://doi.org/10.21873/anticanres.17922
Primary Topic
PI3K/AKT/mTOR signaling in cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Molecular Docking and Inhibition of Phosphatidylinositol 3-kinase by Quercetin and Isoquercetin from Streptomyces griseoaurantiacus HNF214

Waya S. Phutdhawong, THANAPORN CHUEN-IM, THONGCHAI TAECHOWISAN
Anticancer Research
PI3K/AKT/mTOR signaling in cancer
article

Molecular Docking and Inhibition of Phosphatidylinositol 3-kinase by Quercetin and Isoquercetin from Streptomyces griseoaurantiacus HNF214

Waya S. Phutdhawong, THANAPORN CHUEN-IM, THONGCHAI TAECHOWISAN
article en

Abstract

The microbial-derived quercetins effectively induce apoptosis and inhibit HepG2 proliferation by inactivating the PI3K/Akt/mTOR signaling pathway. Quercetin is specifically predicted to directly inhibit PI3K and AKT proteins, underscoring the potential of these compounds as targeted anticancer candidates.

Anticancer ResearchVol. 46(1)
Silpakorn University (TH)
Openalex Percentile: Top 35%
PI3K/AKT/mTOR signaling in cancer
DOISourceOpenAlex
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Molecular Docking and Inhibition of Phosphatidylinositol 3-kinase by Quercetin and Isoquercetin from <i>Streptomyces griseoaurantiacus</i> HNF214 — Waya S. Phutdhawong, THANAPORN CHUEN-IM, et al. · Anticancer Research (2025) | TGRS Research Map | TGRS