Direct Synthesis of (Radio)difluoromethylated Selenides via Organic Photoredox Catalysis

Herein we describe a practical synthesis of difluoromethylated selenides enabled by organophotoredox catalysis. A diverse range of functionalized selenides were efficiently constructed from selenosulfonates and commercially available BTSO₂CF₂H, affording moderate to excellent yields under mild conditions. The protocol features low catalyst loading and operational simplicity. Moreover, this approach has been successfully translated to ¹⁸F-difluoromethylation with high radiochemical conversion, thus providing a streamlined route to potential PET imaging agents.