Quantification methods for 99mTc-labelled disphosphonates uptake in cardiac amyloidosis

Visual grading remains the clinical standard approach. The H/CL ratio is the most reported semi-quantitative method, although it presents some limitations. Absolute quantification with SPECT/CT (SUVmax, SUVpeak) is promising for diagnosis, prognosis, and monitoring of transthyretin amyloidosis (ATTR) CA, yet consensus reference values are lacking.

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Publication Details

Journal
Nuclear Medicine Review
Published
2025-03-10
DOI
https://doi.org/10.5603/nmr.107884
Primary Topic
Amyloidosis: Diagnosis, Treatment, Outcomes
Type
article
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article

Quantification methods for 99mTc-labelled disphosphonates uptake in cardiac amyloidosis

Sérgio Rafael Reis Figueiredo, Maria Neves, José Manuel Belo Ferreira
Nuclear Medicine Review
Amyloidosis: Diagnosis, Treatment, Outcomes
article

Quantification methods for 99mTc-labelled disphosphonates uptake in cardiac amyloidosis

Sérgio Rafael Reis Figueiredo, Maria Neves, José Manuel Belo Ferreira
article en

Abstract

Visual grading remains the clinical standard approach. The H/CL ratio is the most reported semi-quantitative method, although it presents some limitations. Absolute quantification with SPECT/CT (SUVmax, SUVpeak) is promising for diagnosis, prognosis, and monitoring of transthyretin amyloidosis (ATTR) CA, yet consensus reference values are lacking.

Nuclear Medicine ReviewVol. 28(0)
Universidade Politécnica de Lisboa (PT)
Openalex Percentile: Top 35%
Amyloidosis: Diagnosis, Treatment, Outcomes
DOIOpen Access PDFOpenAlex
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Quantification methods for 99mTc-labelled disphosphonates uptake in cardiac amyloidosis — Sérgio Rafael Reis Figueiredo, Maria Neves, et al. · Nuclear Medicine Review (2025) | TGRS Research Map | TGRS