Identifying Differentially Methylated Sites for Methylation-Sensitive qPCR-based NIPT of Trisomies 13 and 18
MS-qPCR represents a promising alternative to NGS for NIPT, offering a scalable, cost-effective solution for detecting trisomies 13 and 18. Future research should validate these findings using cell-free DNA (cfDNA) in maternal plasma and expand testing to diverse populations.
Authors
- Mohammad Hossein Modarressi (ORCID: https://orcid.org/0000-0003-2763-1964)
- Ghazal Sedaghat Shayegan
- Ali Najafi (ORCID: https://orcid.org/0000-0001-7133-5244)
- Mohammad Miryounesi
- Morteza Rajabi
- Artin Mehrabani
- Erfaneh Dastbaz
Institutions
- University of Tehran (IR)
- Islamic Azad University Central Tehran Branch (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Advanced Biomedical Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.4103/abr.abr_37_25
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00