Physicochemical features of intrinsically disordered regions predict DNA-demethylation-promoting activity of transcription factors
The developed model with high predictive performance and the predicted TFs with DNA-demethylation-promoting activity will be useful for further analysis of TFs involved in generation of DNA methylation profiles in normal cell development and disease.
Authors
- Yuri Nakanishi
- Feifei Wei (ORCID: https://orcid.org/0000-0001-6048-8894)
- Xian-Yang Qin
- Harukazu Suzuki
- Shiori Maeda
- Yuta Sakamoto
- Hajime Nishimura
Institutions
- Kanagawa Prefectural Hospital Organization (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1186/s13072-025-00655-w
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00