Immune Checkpoint Inhibitor-Induced Concomitant Polyradiculoneuritis and Myocarditis With Positive Anti-Titin Antibodies: A Case Report and Literature Review
This is the first reported case of seropositive, overlap irAEs consisting of myocarditis and polyradiculoneuritis. Early immunosuppressive therapy can alleviate irAEs but can also lead to serious complications in frail patients. This underscores the importance of carefully balancing expected therapeutic benefits against potential risks.
Authors
- Soraya Benguerfi (ORCID: https://orcid.org/0000-0003-1596-493X)
- Manuel Laslandes (ORCID: https://orcid.org/0009-0005-4210-3248)
- Bénédicte Piron (ORCID: https://orcid.org/0009-0003-7960-7330)
- Emmanuel Canet
- Marie Cap
- Antonin Courant
Institutions
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre d'Investigation Clinique de Nantes (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1097/cce.0000000000001363
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05