Targeting IQGAP3 skews macrophages polarization towards M1 phenotype and promotes antitumor immune response
IQGAP3 drives immunosuppressive macrophage polarization in LUAD. Its inhibition represents a novel strategy to improve immunotherapy response.
Authors
- Ji Shi (ORCID: https://orcid.org/0000-0002-6409-4662)
- Shijun Zhang (ORCID: https://orcid.org/0009-0007-7345-4555)
- Y J Wang
- Yuanyi Zhang (ORCID: https://orcid.org/0000-0002-2609-5672)
- Li Xiao (ORCID: https://orcid.org/0000-0002-3627-2513)
- Yao Xu
- Bo Yuan (ORCID: https://orcid.org/0000-0001-8565-5994)
- Lizhong Zeng
- Shiqi Wu
- Xin Lv
- Xiaopeng An
- Shuanying Yang
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Shandong Provincial QianFoShan Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1007/s00018-025-06044-6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00