Comparison of three PEG precipitation protocols for the detection of macrovitamin B12 interference

The presence of macrovitamin B12 (macroB12) in serum inferfers in result interpretation of total vitamin B12 (B12) result and can lead to misidentification of deficiency. Polyethylene glycol (PEG) precipitation is a non-specific method that removes macromolecules (protein polymers and antibody-bound analytes) allowing measurment of circulating vitamin B12 (i.e. B12 bound to transcobalamin and haptocorrin).

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Publication Details

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Open Repository and Bibliography (University of Liège)
Published
2025-11-13
Primary Topic
Folate and B Vitamins Research
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article
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article

Comparison of three PEG precipitation protocols for the detection of macrovitamin B12 interference

Étienne Cavalier, Laura Vranken, Grace DIEUPE
Open Repository and Bibliography (University of Liège)
Folate and B Vitamins Research
article

Comparison of three PEG precipitation protocols for the detection of macrovitamin B12 interference

Étienne Cavalier, Laura Vranken, Grace DIEUPE
article en

Abstract

The presence of macrovitamin B12 (macroB12) in serum inferfers in result interpretation of total vitamin B12 (B12) result and can lead to misidentification of deficiency. Polyethylene glycol (PEG) precipitation is a non-specific method that removes macromolecules (protein polymers and antibody-bound analytes) allowing measurment of circulating vitamin B12 (i.e. B12 bound to transcobalamin and haptocorrin).

Open Repository and Bibliography (University of Liège)
Openalex Percentile: Top 27%
Folate and B Vitamins Research
Open Access PDFOpenAlex
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Comparison of three PEG precipitation protocols for the detection of macrovitamin B12 interference — Étienne Cavalier, Laura Vranken, et al. · Open Repository and Bibliography (University of Liège) (2025) | TGRS Research Map | TGRS