Comparative study of behavior and pathology in three mouse models of kainic acid–induced epilepsy
The intravenous + kainic acid model exhibited low mortality, reduced dosage requirements, and inducible localized pathological damage, rendering it suitable for investigating localized neuronal injury. The intraperitoneal method, though simple with higher mortality, is preferable for systemic seizure models. The noninvasive intranasal approach is promising for trauma-sensitive research.
Authors
- Dong Hu (ORCID: https://orcid.org/0000-0002-3992-9680)
- Lijun Zhang (ORCID: https://orcid.org/0000-0002-1958-9404)
- Wei Rong (ORCID: https://orcid.org/0000-0002-8550-6574)
- Fei Song
- Cheng Zhang
- Lingan Huang
- Jianjin Zhu
- SongHua Xiao
Institutions
- Chinese Academy of Sciences (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Neuroreport
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1097/wnr.0000000000002238
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00