Metformin reshapes the tumor microenvironment and enhances prognosis in invasive pancreatic ductal adenocarcinoma with diabetes mellitus
Metformin may enhance the infiltration of cytotoxic CD8(+) T cells into the tumor microenvironment and improve the prognosis of diabetic patients with PDAC, particularly in those undergoing upfront surgical resection.
Authors
- Hisanaga Horie
- Hironori Yamaguchi
- Naohiro Sata
- Y. Hosoya
- J. Kitayama
- Hiroshi Kawahira
- Hideyuki Ohzawa
- Kazuhiro Endo (ORCID: https://orcid.org/0000-0002-2845-3533)
- Yuichi Aoki (ORCID: https://orcid.org/0000-0003-3280-5076)
- Hideki Sasanuma
- Toshiki Mimura
- Rei Takahashi
- Yuki Kimura
- Masanobu Taguchi
- Kazue Morishima
- Akira Saito
- Hideyo Miyato
Institutions
- Jichi Medical University (JP)
- Jichi Medical University Hospital (JP)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/jgo-2025-457
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00