α-Glycosidase activity of novel coumarin–triazole–coumarin dyads
Novel coumarin-triazole-coumarin dyads were synthesized and characterized, and their α-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC<sub>50</sub> value of 38.98 ± 0.77 μM. The IC<sub>50</sub> values for 4d and 4a were 93.55 ± 1.70 μM and 95.04 ± 3.55 μM, respectively. The Lineweaver-Burk plot showed that 4e inhibited α-glycosidase in a mixed type. In addition, the <i>K</i> <i><sub>i</sub></i> value obtained from the Dixon plot was 19.95 ± 0.15 μM for α-glycosidase.
Authors
- Burak Barut (ORCID: https://orcid.org/0000-0002-7441-8771)
- Gökçe Seyhan (ORCID: https://orcid.org/0000-0002-8553-9093)
- Baybars Köksoy (ORCID: https://orcid.org/0000-0001-7939-5380)
- Esra Sevimli (ORCID: https://orcid.org/0000-0002-7935-3954)
- YUNUS KAYA
- ERSİN ŞİRİN
Institutions
- Karadeniz Technical University (TR)
- Bursa Technical University (TR)
Publication Details
- Journal
- TURKISH JOURNAL OF CHEMISTRY
- Published
- 2025-12-25
- DOI
- https://doi.org/10.55730/1300-0527.3770
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00