299 Risk Factors for Readmission Post-Oesophagectomy

Abstract Aim Hospital readmission following curative oesophagectomy for oesophageal cancer, affects approximately one-quarter of patients. Previous studies have linked readmission with increased morbidity and mortality; however, factors contributing to readmission remain poorly understood. This study aimed to identify potential risk factors for hospital readmission following oesophagectomy. Method This retrospective study included all patients who underwent curative oesophagectomy between 2017 and 2024 at a single high-volume centre. The primary outcome was 30-day hospital readmission following discharge. Predictor variables included demographics, and pre-, intra-, and post-operative factors, including complications. Multivariable analysis identified associations with readmission, while Cox models assessed its impact on recurrence-free and overall survival. Results Of 492 patients, 130 (26.4%) were readmitted within 30 days. Multivariable analysis found female sex (OR 2.00), major complications (CD ≥3) (OR 5.1), and minor complications (CD 1–2) (OR 2.48) were linked to higher readmission risk. Neo-adjuvant chemotherapy was associated with lower odds (OR 0.54). Pre-operative, intraoperative factors, and ICU/hospital stay duration showed no independent association with readmission. Conclusions This study highlights that hospital readmission within 30 days of oesophagectomy remains a significant issue, affecting 26% of patients. Female sex and the occurrence of minor or major post-operative complications were the only independent risk factors for readmission. These findings suggest that targeted post-discharge monitoring and tailored care strategies might be beneficial for patients at higher risk.