ZNF454-FSTL3 axis inhibits colorectal cancer progression by inhibiting HIF-1α-mediated glycolysis in hypoxia
Collectively, our findings demonstrate that ZNF454 suppresses CRC development by inhibiting FSTL3/HIF-1α-mediated glycolysis through transcriptional repression of FSTL3. This study is the first to reveal the molecular mechanism responsible for FSTL3 overexpression in CRC, providing a novel perspective for CRC treatment.
Authors
- Lin Qin (ORCID: https://orcid.org/0000-0002-3483-0622)
- Dajun Wu
- Yueming Wu
- Chao Zhang
- Pingfei Tang
- Lin Tan
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/jgo-2025-326
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00