Effect of Autologous Nanofat Graft in the Management of Chronic Benign Ulcers in Suez Canal University Hospital

Background: Treatment of chronic ulcers is a challenging process. Autologous fat graft has gained interest with introduction of nanofat technology. Aim: The current study aimed to compare nanofat grafting vs topical antibiotic dressing in management of chronic benign ulcers regarding the regenerative & healing outcome. Patients & methods: This randomized controlled clinical trial was conducted among a total of 20 patients with chronic benign ulcers. The patients have been divided into two treatment groups: Group 1 included 10 patients treated with nanofat grafting & group 2 included 10 patients treated with conservative management (as control). Patients were followed up for 4 months & evaluated for degree of healing (no healing, partial and complete). The ulcers were evaluated for area, circumference & depth at the start and at the end of the follow up period. Results: The most common cause of the ulcer was found to be post-inflammatory; 40% among nanofat graft group & 50% of the conservative group patients. Nanofat grafting showed significantly smaller area compared to control group after 1 month of follow up. Only one patient of the conservative group showed no healing at the end of follow up period versus none of the nanofat graft group. Complete healing was reported among 80% of the nanofat graft group versus 20% of the conservative group patients with statistically significant difference between both groups. The most common side effect was donor site edema (30%). None of the studied patients had injection site infection or seroma. Conclusion: Nanofat grafting was effective therapeutic procedure for treatment of chronic benign ulcers, which reduce time to healing than other methods.