MicroRNA isomiRs reveal novel pathways linked to disease activity and fibrosis in MASLD
IsomiRs represent the majority of hepatic miRNAs and uncover novel regulatory networks masked by canonical miRNA analysis. These findings provide new insights into the molecular heterogeneity of MASLD, highlight candidate pathways driving disease progression, and identify potential biomarker and therapeutic targets for precision hepatology.
Authors
- F. Mirshahi
- Mohammad Shadab Siddiqui (ORCID: https://orcid.org/0000-0001-7392-7489)
- David W. Salzman
- Molly A. Srour
- Amon Asgharpour
- Bhanu Sakhamuri
- Stephen A. Hoang (ORCID: https://orcid.org/0000-0002-4413-6036)
- Jessie Ang
- Matthew Long
- David J. Hayes
- Neal C. Foster
- Christian Brion
- Arun J. Sanyal
- Zheng Zhu
- Guangliang Wang
Institutions
- Strathmore University (KE)
- Virginia Commonwealth University (US)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.3350/cmh.2025.0933
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Gilead Sciences
- Virginia Commonwealth University
- Novo Nordisk
- National Institutes of Health