Landscape of Phenotype-Genotype Correlations in Romanian Patients with Medullary Thyroid Carcinoma
Germline RET screening is mandatory for all MTC cases. Somatic testing is critical in advanced disease, where M918T prevails in 75% of cases and guides tyrosine kinase inhibitor therapy. Codon 634 is the most frequent mutation in Romanian MTC, highlighting regional variation warranting population-adjusted screening and earlier prophylactic thyroidectomy.
Authors
- Elena Braha
- Sorina Schipor (ORCID: https://orcid.org/0000-0002-4886-2174)
- Laura-Semonia Stanescu
- Monica Livia Gheorghiu (ORCID: https://orcid.org/0000-0002-1754-5619)
- Corin Virgil Badiu
- Sofia-Maria Lider-Burciulescu
- Andrei Muresan
Institutions
- Carol Davila University of Medicine and Pharmacy (RO)
- Institutul Național de Endocrinologie C.I. Parhon (RO)
- National Center for Geriatrics and Gerontology (JP)
Publication Details
- Journal
- Cancers
- Published
- 2025-12-27
- DOI
- https://doi.org/10.3390/cancers18010093
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00