Unraveling Key Regulatory Pathways in Non-HCV-Induced Hepatocellular Carcinoma: Insights from Exclusively Mutated Genes and Prognostic Biomarkers
Clinically, FGFR1/MET co-alterations predicted significantly worse outcomes (HR=2.3 for recurrence, 95% CI 1.1-4.8), while maintaining 92% specificity for non-viral HCC diagnosis. These findings establish the FGFR1-MET-ERBB2 axis as both a molecular classifier and therapeutic target, providing a rationale for etiology-specific management strategies in HCC precision oncology.
Authors
- Ahmed R. Sofy (ORCID: https://orcid.org/0000-0003-2685-5851)
- Ahmed A. Hmed
- Manal Elhamshary
- Khaled S Elfeky
- Mohamed Khalifa
- Sayed Bakry
Institutions
- Al-Azhar University (EG)
- University of Sadat City (EG)
- Children Cancer Hospital (EG)
Publication Details
- Journal
- Asian Pacific Journal of Cancer Prevention
- Published
- 2025-12-01
- DOI
- https://doi.org/10.31557/apjcp.2025.26.12.4593
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00