Apelin‐13 Attenuates Blood–Brain Barrier Dysfunction Following Intracerebral Hemorrhage via Targeting the Keap1/Nrf2 Signaling

In conclusion, these findings demonstrate that through its engagement with APJ, Apelin-13 activates the endothelial Keap1/Nrf2 pathway to protect against ICH-induced BBB disruption and facilitate neurological recovery, highlighting its therapeutic promise for ICH.

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Publication Details

Journal
CNS Neuroscience & Therapeutics
Published
2025-12-01
DOI
https://doi.org/10.1002/cns.70706
Citations
1
Primary Topic
Apelin-related biomedical research
Type
article
Field-Weighted Citation Impact
1.39
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article

Apelin‐13 Attenuates Blood–Brain Barrier Dysfunction Following Intracerebral Hemorrhage via Targeting the Keap1/Nrf2 Signaling

Juanfeng Qian, Mengzhou Xue, Lingxiao Qi, Pingping Guo et al.
1 citations
CNS Neuroscience & Therapeutics
Apelin-related biomedical research
1.39
article

Apelin‐13 Attenuates Blood–Brain Barrier Dysfunction Following Intracerebral Hemorrhage via Targeting the Keap1/Nrf2 Signaling

Juanfeng Qian, Mengzhou Xue, Lingxiao Qi, Pingping Guo, Rabeea Siddique, V. Wee Yong
article en
1 citations

Abstract

In conclusion, these findings demonstrate that through its engagement with APJ, Apelin-13 activates the endothelial Keap1/Nrf2 pathway to protect against ICH-induced BBB disruption and facilitate neurological recovery, highlighting its therapeutic promise for ICH.

CNS Neuroscience & TherapeuticsVol. 31(12)
Allen Institute for Brain Science (US), University of Calgary (CA), Zhengzhou University (CN), Henan Academy of Sciences (CN), Second Affiliated Hospital of Zhengzhou University (CN)
Openalex Percentile: Top 13%
Apelin-related biomedical research
1.39
DOIOpen Access PDFOpenAlex
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