Evidence of recent natural selection at Alzheimer Disease risk loci and implications for precision medicine
At least 26 LOAD risk loci show evidence of recent evolutionary selection. Pathway analyses indicate that evolution may be acting on distinct biological functions in each superpopulation. Selection on microtubule function in Africans may align with observed differences in Tau physiology in African Americans. Thus, LOAD etiology and comorbidity/pre-morbidity patterns may differ by superpopulation. Research and interventions may need to be tailored.
Authors
- Giuseppe Tosto (ORCID: https://orcid.org/0000-0001-7075-8245)
- Scott M. Williams (ORCID: https://orcid.org/0000-0002-4835-9544)
- Rufus Akinyemi (ORCID: https://orcid.org/0000-0001-5286-428X)
- Maryenela Illanes‐Manrique (ORCID: https://orcid.org/0000-0002-3098-0981)
- Razaq O Durodoye
- Neetesh Kumar Pandey
- R. Wong
- Timothy H. Ciesielski
- Mario Cornejo‐Olivas
- Rafael Samper‐Ternent
- Margaret Pericak‐Vance
- Jonathan L Haines
- Nilton Custodio
- Farid Rajabli
- Himiede Sesay
Institutions
- NewYork–Presbyterian Hospital (US)
- University of Miami (US)
- University of Ibadan (NG)
- Universidad Científica del Sur (PE)
- Presbyterian Hospital (US)
- Dr. John T. Macdonald Foundation (US)
- Institute of Peruvian Studies (PE)
- University School (US)
- The University of Texas at San Antonio (US)
- The University of Texas Medical Branch at Galveston (US)
- Case Western Reserve University (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107509
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00