Apathy, depression, and dementia risk in older adults: A global collaborative study
Harmonized data from 10 population-based cohorts across six continents were used. Apathy predicted dementia only in older adults with both depression and mild cognitive impairment. No association was found in non-depressed or cognitively normal individuals. Monitoring progression of affective symptoms may aid dementia risk stratification.
Authors
- M. Yannakoulia
- Seung‐Ho Ryu (ORCID: https://orcid.org/0000-0001-8057-8723)
- Jong Chul Youn (ORCID: https://orcid.org/0000-0002-2904-8951)
- Fleur Harrison (ORCID: https://orcid.org/0000-0002-3432-7955)
- S. A. Lee
- Alexander Pabst (ORCID: https://orcid.org/0000-0003-0432-5681)
- Joonhyuk Park (ORCID: https://orcid.org/0000-0002-3100-5934)
- Ji Won Han (ORCID: https://orcid.org/0000-0003-2418-4257)
- Tae Hui Kim (ORCID: https://orcid.org/0000-0003-0133-5227)
- Daniel Davis (ORCID: https://orcid.org/0000-0002-1560-1955)
- Elena Rolandi (ORCID: https://orcid.org/0000-0003-0043-2471)
- Darren M. Lipnicki (ORCID: https://orcid.org/0000-0002-1684-3577)
- Akin Ojagbemi
- N. Scarmeas
- Dae Jong Oh
- Oye Gureje
- H Brodaty
- Bong Jo Kim
- Susanne Roehr
- Jeong Lan Kim
- Jin Hyeong Jhoo
- Dong Woo Lee
- Seok Woo Moon
- Annalisa Davin
- Ki Woong Kim
- Pierre‐Marie Preux
- Mindy J. Katz
- Perminder S. Sachdev
- Michele Rossi
- Shin Gyeom Kim
- Mary Kosmidis
- Erico Castro‐Costa
- Steffi Riedel‐Heller
- Dong Young Lee
- Kyung Phil Kwak
- Richard B. Lipton
- Olufisayo Elugbadebo
- Maëlenn Guerchet
- Jung Jae Lee
Institutions
- Albert Einstein College of Medicine (US)
- Seoul National University (KR)
- Inserm (FR)
- Kangwon National University (KR)
- University of Ibadan (NG)
- Gyeongju University (KR)
- Gyeongsang National University (KR)
- Chungnam National University (KR)
- National and Kapodistrian University of Athens (GR)
- Dongguk University (KR)
- Aristotle University of Thessaloniki (GR)
- Konkuk University (KR)
- University of Cambridge (GB)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- UNSW Sydney (AU)
- Harokopio University of Athens (GR)
- Cambridge School (PT)
- Konkuk University Medical Center (KR)
- Wonju Severance Christian Hospital (KR)
- Kangbuk Samsung Hospital (KR)
- Fondazione Golgi Cenci (IT)
- Inje University Sanggye Paik Hospital (KR)
- Université d'Abomey-Calavi (BJ)
- Yongin Mental Hospital (KR)
- Institut d’Epidémiologie Neurologique et de Neurologie Tropicale (FR)
- Global Brain Health Institute (US)
- Prefeitura Municipal de Belo Horizonte (BR)
- Jeju National University Hospital (KR)
- Institut de Recherche pour le Développement (FR)
- Dankook University Hospital (KR)
- Massey University (NZ)
- Bucheon University (KR)
- Université de Limoges (FR)
- Columbia University (US)
- Jeju National University (KR)
- Leipzig University (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71059
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Wellcome Trust
- European Commission
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- AXA Research Fund
- Ministério da Saúde
- Universität Leipzig
- National Institutes of Health
- Centers for Disease Control and Prevention
- Medical Research Council
- National Health and Medical Research Council
- Korea Centers for Disease Control and Prevention