Alternation of the oral, gastric and stool microbiome in patients with reflux esophagitis and Barrett's esophagus
The increased abundance of Tannerellaceae in saliva was correlated with elevated serum IL-6 levels and may be a contributing factor in chronic esophageal reflux disease. BE patients had a higher abundance of Prevotella, a gram-negative bacterium, which may be linked to early stage esophageal inflammation in chronic reflux disease. Conversely, the increased abundance of Helicobacter in gastric juice may serve as a protective factor.
Authors
- Ming‐Chao Tsai
- Yuan-Hung Kuo
- Wei-Chen Tai
- Cheng-Kun Wu (ORCID: https://orcid.org/0000-0002-5387-3046)
- Yu-Chieh Tsai
- Chih-Chien Yao
- Pao-Yuan Huang
- Chung-Mou Kuo
- Chih-Ming Liang
- Wei-Shiung Lian
- Seng-Kee Chuah
- Yi-Chun Chiu
- Chien-Hung Chen
- Keng-Liang Wu
Institutions
- Chang Gung University (TW)
- Second Military Medical University (CN)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Eastern Hepatobiliary Surgery Hospital (CN)
- Kaohsiung Municipal Ta-Tung Hospital (TW)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jmii.2025.12.007
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00