Single-Cell RNA sequencing identifies NAMPT as a potential therapeutic target in autoimmune uveitis
Inhibiting NAMPT can reverse the imbalance of effector T (Teff)/Treg cells by suppressing the expression of Hif1α in CD4<sup>+</sup>T cells, thereby effectively alleviating the symptoms of EAU. Therefore, NAMPT might be a potential target for AU.
Authors
- Shenqian Tian
- Yingying Wen (ORCID: https://orcid.org/0000-0003-4327-6368)
- Yihan Zhang (ORCID: https://orcid.org/0000-0003-1566-5972)
- Dongting Wu
- Zhaohao Huang (ORCID: https://orcid.org/0000-0002-6958-2673)
- G H Jiang
- Genxian Zhang
- Wenru Su (ORCID: https://orcid.org/0000-0002-0506-6362)
- Yue Peng
- Lei Zhu
- Xuling Chen
- He Li
Institutions
- Qinghai University (CN)
- Sun Yat-sen University (CN)
- Bengbu Medical College (CN)
- Shanghai Ninth People's Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.030
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 0.00