Study the Role of Vitamin D Supplements on NAFLD Associated with Elevated Liver Enzymes in Diabetic and non-Diabetic Patients

Background: Non-alcoholic fatty liver disease (NAFLD) is recongized as fatty infiltration of the liver, which is confirmed by histopathology or radiology in the lack of further reasons for steatosis, like viral hepatitis, medication-caused elevated liver enzymes, and alcoholic liver disease. The aim is to evaluate the role of vitamin D supplements on NAFLD in diabetic and nondiabetic patients with elevated liver enzymes. Methods: This cross-sectional study was performed on 130 NAFLD in diabetic (n=65) and non-diabetic (n=65) with elevated liver enzymes and vitamin D deficiency. Patients were re-evaluated after 12 weeks of vitamin D supplementation. At follow-up, ALT, AST, HbA1c, random glucose, serum 25(OH)D level, BMI, and waist circumference were repeated.Results Both groups showed significant improvements in vitamin D levels, liver enzymes, and HbA1c after supplementation. Non-diabetic patients had a greater reduction in ALT and AST compared to diabetics (P value <0.001). However, the decrease in HbA1c was more pronounced in diabetics (P value <0.001).Conclusions: Non-diabetic patients experienced greater reductions in hepatic enzymes, while diabetic patients showed a more marked improvement in glycemic control, suggesting distinct yet complementary advantages of vitamin D in these populaces.