Plasma Concentrations of Prophylactic Posaconazole and Risk Factors for Subtherapeutic Exposure in Taiwanese Patients with Hematologic Malignancies

Subtherapeutic and supratherapeutic exposures to posaconazole remain a concern despite standard dosing. Therapeutic drug monitoring and personalized risk assessment are essential for optimizing antifungal prophylaxis in patients with hematologic malignancies.

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Publication Details

Journal
Drug Design Development and Therapy
Published
2025-12-01
DOI
https://doi.org/10.2147/dddt.s557802
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
0.00

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article

Plasma Concentrations of Prophylactic Posaconazole and Risk Factors for Subtherapeutic Exposure in Taiwanese Patients with Hematologic Malignancies

Tsung-Yu Pai, Hsing-Yu Lin, Chien-Chih Wu, Fang-Ju Lin et al.
Drug Design Development and Therapy
Antifungal resistance and susceptibility
article

Plasma Concentrations of Prophylactic Posaconazole and Risk Factors for Subtherapeutic Exposure in Taiwanese Patients with Hematologic Malignancies

Tsung-Yu Pai, Hsing-Yu Lin, Chien-Chih Wu, Fang-Ju Lin, Shu-Chen Hu
article en

Abstract

Subtherapeutic and supratherapeutic exposures to posaconazole remain a concern despite standard dosing. Therapeutic drug monitoring and personalized risk assessment are essential for optimizing antifungal prophylaxis in patients with hematologic malignancies.

Drug Design Development and TherapyVol. Volume 19
National Taiwan University (TW), National Taiwan University Hospital (TW), Kaohsiung Veterans General Hospital (TW)
National Taiwan University Hospital, National Taiwan University
Good health and well-being
Openalex Percentile: Top 30%
Antifungal resistance and susceptibility
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