Association of the -4719A/T Polymorphism in the RAD51 Gene with Demographic and Clinicopathological Features of Lung Cancer in Iraqi Patients

This study is among the first to investigate the -4719A/T (rs2619679) polymorphism in the RAD51 gene and its association with lung cancer in the Iraqi population. A statistically significant association was identified between this variant and lung cancer risk. The genotypic patterns identified suggest that the presence of the T allele particularly in the more frequently occurring heterozygous AT genotype may contribute to the molecular mechanisms involved in lung cancer development through its impact on DNA repair processes.

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Publication Details

Journal
Asian Pacific Journal of Cancer Prevention
Published
2025-12-01
DOI
https://doi.org/10.31557/apjcp.2025.26.12.4585
Primary Topic
DNA Repair Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Association of the -4719A/T Polymorphism in the RAD51 Gene with Demographic and Clinicopathological Features of Lung Cancer in Iraqi Patients

Zahraa Muhammed Jabur, Rand Mohammed Abdul-Hussein
Asian Pacific Journal of Cancer Prevention
DNA Repair Mechanisms
article

Association of the -4719A/T Polymorphism in the RAD51 Gene with Demographic and Clinicopathological Features of Lung Cancer in Iraqi Patients

Zahraa Muhammed Jabur, Rand Mohammed Abdul-Hussein
article en

Abstract

This study is among the first to investigate the -4719A/T (rs2619679) polymorphism in the RAD51 gene and its association with lung cancer in the Iraqi population. A statistically significant association was identified between this variant and lung cancer risk. The genotypic patterns identified suggest that the presence of the T allele particularly in the more frequently occurring heterozygous AT genotype may contribute to the molecular mechanisms involved in lung cancer development through its impact on DNA repair processes.

Asian Pacific Journal of Cancer PreventionVol. 26(12)
University of Kufa (IQ)
University of Kufa
Good health and well-being
Openalex Percentile: Top 35%
DNA Repair Mechanisms
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Association of the -4719A/T Polymorphism in the RAD51 Gene with Demographic and Clinicopathological Features of Lung Cancer in Iraqi Patients — Zahraa Muhammed Jabur, Rand Mohammed Abdul-Hussein · Asian Pacific Journal of Cancer Prevention (2025) | TGRS Research Map | TGRS