Thbs1+ extracellular vesicles from irradiated tumors induce cardiac wasting via PERK-eIF2α-Atf4 signaling
These results indicate that radiotherapy promotes the release of Thbs1<sup>+</sup> EVs, which drive cardiac muscle wasting via PERK-eIF2α-Atf4 signaling, revealing a novel mechanism underlying cancer-associated cardiac damage.
Authors
- Zhirui Shan
- J. He (ORCID: https://orcid.org/0000-0001-9642-0963)
- Zicheng Zhang
- Wenzhi Liu
- Song Gao
- Yue Wang
- Tian Li
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Tianjin Nankai Hospital (CN)
- Shenzhen Luohu People's Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.053
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00