False positive plasma p‐tau217 results associated with heterophilic antibody interference: A potential clinical pitfall
Potential heterophile antibody (HAb) interference in the Lumipulse p-tau217 immunoassay was investigated. Investigation was performed using HAb blocking reagent, and in some cases also using PEG precipitation . Patients with p-tau217 concentrations > 10 pg/mL exhibited positive HAb interference in 14 of 15 cases. HAb interference can lead to falsely positive p-tau217/Aβ42 ratios.
Authors
- Alicia Algeciras‐Schimnich (ORCID: https://orcid.org/0000-0002-4455-6217)
- Susan Ashrafzadeh Kian
- Joshua A. Bornhorst (ORCID: https://orcid.org/0009-0003-9297-3271)
- Daniel J. Figdore (ORCID: https://orcid.org/0000-0002-4776-3203)
- J Paul Theobald
Institutions
- Mayo Clinic (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71045
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00