342 Prognostic Significance of SUVmax from PET/CT in the Recurrence of Colorectal Liver Metastasis

Abstract Introduction Fifty percent of the patients with colorectal liver metastasis experience recurrence in the liver. Early recurrence in the liver significantly impacts survival and the means to identify those at higher risk of recurrence have gained interest. There is increasing interest in assessing the degree of avidity on PET-CT scan as a tool to predict overall (OS) and recurrence free survival (RFS). Objective The current study aims to explore the relationship between the SUVmax of liver lesions on PET-CT and RFS. Method Total of 80 pts who had pre-operative PET-CT scans prior to liver resection (between 2014-2022) were included in this retrospective, single-center analysis. SUVmax values were categorised to low, medium-low, medium-high and high grades and the incidence of early liver recurrence (within 12months of liver resection) were compared among these groups. Results The cohort had a mean age of 60 years, with rectal cancer being the most common primary site (38%). 30% had synchronous disease and 30% had early recurrence. Mean Fong score was 1.64 (CI:1.47-1.81) and mean TBS was 14.65 (CI:10.51-18.79). Multivariate analysis revealed a significant association between SUVmax and early liver recurrence, with an odds ratio (OR) of 1.96 (95% CI: 1.07-3.61). Resection margin status was also a significant factor (OR = 3.54; 95% CI: 1.45-8.69). Kaplan-Meier analysis confirmed the relationship between SUVmax and RFS (p=0.046). Conclusions SUVmax from PET-CT may serve as a prognostic tool for predicting early liver recurrence in CRLM patients. The results need validation from larger multicentre studies.