Transglutaminase‐2 Promotes Microglial Synaptic Phagocytosis and Ameliorates Epileptic Seizures by Inhibiting <scp>ABCA1</scp> Ubiquitination
This study revealed that TGM2 suppresses epileptogenesis by enhancing microglial synaptic phagocytosis through the inhibition of ABCA1 ubiquitination, thereby regulating synaptic remodeling in the hippocampus. These findings establish a critical molecular link between TGM2-mediated microglial function and epileptogenesis, providing novel insights into therapeutic strategies targeting neuroinflammation and synaptic plasticity in epilepsy.
Authors
- Zhong Hua Luo
- Xiao-Yan Yang (ORCID: https://orcid.org/0000-0002-0957-759X)
- Hanmo Zhang (ORCID: https://orcid.org/0000-0003-0363-2831)
- Juan Li (ORCID: https://orcid.org/0000-0003-0905-7188)
- Changyin Yu
- Juan Yang (ORCID: https://orcid.org/0000-0001-6538-4381)
- XC Wang
- Qianqiong Qin
- Zunlin Zhou
- Jun Tian
- Jiyao Qin
- Xin Xu
- Hao Huang
- Bidan Feng
- Zucai Xu
Institutions
- Zunyi Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cns.70725
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00