Discovery of a small-molecule inhibitor of eIF4E suppressing tumor proliferation via lipid metabolic reprogramming
Together, our results demonstrate that b14 is an excellent novel small-molecule inhibitor of eIF4E for future cancer therapy.
Authors
- Yuxi Lin (ORCID: https://orcid.org/0000-0001-7210-2557)
- Xiaoyi bai
- Dayong Shi
- Pan Xing
- Jiqiang Zhu
- Jiashu Chen
- Hao Sun
- Yuanyuan Zhao
- Xiangqian Li
- Yue Xu
- Yanan Gao
- Yiting Zhang
- Chenxia Gao
- Shuo Li
- Feng Xu
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Center of Resource Chemistry and New Materials (CN)
- Shandong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.050
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00