Single-cell and spatial transcriptomics reveal the interaction between PRRX2-driven epithelial cells and SPP1+ macrophages in mediating gemcitabine resistance in pancreatic ductal adenocarcinoma
The results revealed the critical role of PRRX2+EC/SPP1+TAM cell communication in mediating gemcitabine resistance in PDAC. These findings provide new insights into potential therapeutic strategies, highlighting the importance of targeting the PRRX2+EC/SPP1+TAM axis and supporting the use of multidrug regimens to overcome resistance and improve patient outcomes in PDAC.
Authors
- Zhihua Pei
- Guanhua Liu (ORCID: https://orcid.org/0000-0002-0824-9738)
- F Li
- W. G. Liu
- Jingmei Liu (ORCID: https://orcid.org/0000-0003-1938-7930)
- Lijuan Huo
- Zhilong Li
- Wenhui Yang
Institutions
- Shanxi Medical University (CN)
- Huazhong Agricultural University (CN)
- Shanxi Provincial Cancer Hospital (CN)
- Chinese Institute for Brain Research (CN)
- Ministry of Science and Technology (VN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1097/cm9.0000000000003966
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00